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Lipid Nanoparticles (LNPs)

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Artificial Cell, Lipid Nanoparticles (LNPs)
"ProtoCell Concept"

Nanoscale self-assembly is imperative in the fabrication of lipid nanoparticles (LNPs). We leverage artificial intelligence (AI) to select lipid compositions that confer LNPs with dual-functionality, which are capable of in vivo targeted delivery of active functional molecules with reduced toxicity effects while offering protection and stabilization to the active functional molecules.

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56

Tae H, Park S, Tan LY, Yang C, Lee YA, Choe YH, Wüstefeld T, Jung S*, and Cho NJ*

"Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems" 

ACS Nano 2024. (April 19, 2024)

55

Sut TN,  Park S, Jackman JA**, Cho NJ** 

(** denotes equal corresponding authors)

"Controlling molecular self-assembly of inverse-phosphocholine lipids at oxide interfaces with divalent cations" 

Applied Materials Today 35 (2023) 101953

54

Hyeonjin Park, Tun Naw Sut, Bo Kyeong Yoon, Vladimir P. Zhdanov, Nam-Joon Cho*, and Joshua A. Jackman*

"Unraveling How Cholesterol Affects Multivalency-Induced Membrane Deformation of Sub-100 nm Lipid Vesicles" 

Langmuir, 2022.

53

Sut TN, Ferhan AR, Park S, Koo DJ, Yoon BK, Jackman JA*, and Cho NJ*

"Modulating noncovalent and covalent forces to control inverse phosphocholine lipid self-assembly on inorganic surfaces: Nanoarchitectonic design principles." 

Applied Materials Today, 2022, 29: 101618.

52

Ferhan AR, Park S, Park H, Tae H, Jackman JA*, Cho NJ* 

"Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective.

Advanced Functional Materials, 2022: 2203669.

51

Park H, Sut TN, Yoon BK, Zhdanov VP, Kim JW, Cho NJ*, Jackman JA*

"Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects.

The Journal of Physical Chemistry Letters, 2022, 13: 1480-1488.

49

Sut TN, Yoon BK, Jeon WY, Jackman JA*, Cho NJ*

(* denotes equal corresponding authors)

"Supported Lipid Bilayer Coatings: Fabrication, Bioconjugation, and Diagnostic Applications." 

Applied Materials Today, 2021, 25: 101183.

48

 Tan JYB*, Yoon BK*, Cho NJ, Lovrić J, Jug M, Jackman JA

(* denotes equal first authors)

"Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides.

International Journal of Molecular Sciences, 2021, 22(18): 9664.

47

Yoon BK, Sut TN, Yoo KY, Lee SH, Hwang Y, Jackman JA*, Cho NJ*

(* denotes equal corresponding authors)

"Lipid Bilayer Coatings for Rapid Enzyme-Linked Immunosorbent Assay.

Applied Materials Today 2021, 24: 101128. 

46

Park H*, Sut TN*, Yoon BK, Zhdanov VP, Cho NJ**, Jackman JA**

(* denotes equal first authors, ** denotes equal corresponding authors)

"Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles.

Journal of Physical Chemistry Letters, 2021, 12: 6722-6729.

 
 

45

Jackman JA, Cho NJ

"Supported Lipid Bilayer Formation: Beyond Vesicle Fusion." 

Langmuir 2020; 36, 6,1387-1400.

 

44

Ho JCS, Steininger C, Hiew SH, Kim MC, Reimhult E, Miserez A, Cho NJ, Parikh AN, Liedberg B

 

Cover Illustration

"Minimal Reconstitution of Membranous Web Induced by a Vesicle-Peptide Sol-Gel Transition." 

Biomacromolecules 2019; 20, 4, 1709-1718.

43

Emilsson G, Röder E, Malekian B, Xiong K, Tsai FC, Cho NJ, Bally M, Dahlin A

"Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature."

Frontiers in Chemistry 2019; 7(1), 1-8.

42

Ferhan AR, Špačková B, Jackman JA, Ma GJ, Sut TN, Homola J, Cho NJ

"Nanoplasmonic Ruler for Measuring Separation Distance Between Supported Lipid Bilayer and Oxide Surfaces." 

Analytical Chemistry 2018; 90(21), 12503-12511.

39

Ferhan AR, Jackman JA, Malekian B, Xiong K, Emilsson G, Park S, Dahlin AB, Cho NJ

"Nanoplasmonic Sensing Architectures for Decoding Membrane Curvature-Dependent Biomacromolecular Interactions." 

Analytical Chemistry 2018; 90(12), 7458-7466.

38

Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ

"Interfacial Forces Dictate Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces."

Langmuir 2018; 34(4), 1775-1782.

37

Gillissen JJ, Jackman JA, Tabaei SR, Cho NJ

"A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response." 

Analytical Chemistry 2018; 90(3), 2238-2245.

36

Gillissen JJ*, Tabaei SR*, Jackman JA, Cho NJ

 

(* denotes equal first authors)

"Effect of Glucose on the Mobility of Membrane-Adhering Liposomes." 

Langmuir 2018; 34(1), 503-511.

35

Gillissen JJ, Jackman JA, Tabaei SR, Yoon BK, Cho NJ

"Quartz Crystal Microbalance Model for Quantitatively Probing the Deformation of Adsorbed Particles at Low Surface Coverage." 

Analytical Chemistry 2017; 89(21), 11711-11718.

34

Gillissen JJ, Tabaei SR, Jackman JA, Cho NJ

 

Cover Illustration

"A Model Derived from Hydrodynamic Simulations for Extracting the Size of Spherical Particles from the Quartz Crystal Microbalance." 

Analyst 2017: 142(18), 3370-3379.

33

Ferhan AR, Ma GJ, Jackman JA, Sut TN, Park JH, Cho NJ

"Probing the Interaction of Dielectric Nanoparticles with Supported Lipid Membrane Coatings on Nanoplasmonic Arrays." 

Sensors 2017; 17(7), 1484.

30

Jackman JA, Yorulmaz Avsar S, Ferhan AR, Li D, Park JH, Zhdanov VP, Cho NJ

"Quantitative Profiling of Nanoscale Liposome Deformation by a Localized Surface Plasmon Resonance Sensor." 

Analytical Chemistry 2017: 89(2), 1102-1109.

26

Tabaei SR, Gillissen JJ, Vafaei S, Groves JT, Cho NJ

"Size-Dependent, Stochastic Nature of Lipid Exchange Between Nano-Vesicles and Model Membranes." 

Nanoscale 2016; 8(27), 13513-13520.

25

Dacic M*, Jackman JA*, Yorulmaz S, Zhdanov VP, Kasemo B, Cho NJ

 

(* denotes equal first authors)

"Influence of Divalent Cations on Deformation and Rupture of Adsorbed Lipid Vesicles." 

Langmuir 2016; 32(25), 6486-6495. 

24

Tabaei SR, Gillissen JJ Kim MC, Ho JCS, Liedberg B, Parikh AN, Cho NJ

"Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity." 

Langmuir 2016; 32(21). 5445-5450.

23

Jackman JA, Kim MC, Zhdanov VP, Cho NJ

"Relationship between Vesicle Size and Steric Hindrance Influences Vesicle Rupture on Solid Supports." 

Physical Chemistry Chemical Physics 2016; 18(4), 3065-3072.

22

Kim MC, Gunnarsson A, Tabaei SR, Höök F, Cho NJ

"Supported Lipid Bilayer Repair Mediated by AH Peptide." 

Physical Chemistry Chemical Physics 2016; 18(4), 3040-3047.

21

Jackman JA, Špačková B, Linardy E, Kim MC, Yoon BK, Homola J, Cho NJ

 

Cover Illustration

"Nanoplasmonic Ruler to Measure Lipid Vesicle Deformation." 

Chemical Communications 2016; 52(1), 76-79. 

20

Jeong JH, Choi JH, Kim MC, Park JH, Herrin JS, Kim SH, Lee H, Cho NJ

"Elucidating How Bamboo Salt Interacts with Supported Lipid Membranes: Influence of Alkalinity on Membrane Fluidity." 

European Biophysics Journal 2015; 44(5), 383-391.

19

Tabaei SR, Cho NJ

 

Cover Illustration

"Lamellar Sheet Exfoliation of Single Lipid Vesicles by a Membrane-Active Peptide." 

Chemical Communications 2015; 51(51), 10272-10275. 

18

Oh EK*, Jackman JA*, Yorulmaz S, Zhdanov VP, Lee H, Cho NJ

 

(* denotes equal corresponding authors)

"Contribution of Temperature to Deformation of Adsorbed Vesicles Studied by Nanoplasmonic Biosensing." 

Langmuir 2014; 31(2), 771–781. 

17

Wallin M, Choi JH, Kim SO, Cho NJ, Andersson M

"Peptide‑induced Formation of a Tethered Lipid Bilayer Membrane on Mesoporous Silica." 

European Biophysics Journal 2015; 44(1-2), 27-36.

15

Goh HZ*, Jackman JA*, Kim SO, Cho NJ

Cover Illustration

(* denotes equal first authors)

"Controlling Lipid Membrane Architecture for Tunable Nanoplasmonic Biosensing." 

Small 2014; 10(23), 4828-4832. 

13

Jackman JA, Goh HZ, Zhao Z, Cho NJ

"Contribution of the Hydration Force to Vesicle Adhesion on Titanium Oxide." 

Langmuir 2014; 30(19), 5368–5372.

12

Goh HZ*, Jackman JA*, Cho NJ

 

(* denotes equal first authors)

"AH Peptide-Mediated Formation of Charged Planar Lipid Bilayers." 

The Journal of Physical Chemistry B 2014; 118(13), 3616-3621.

11

Jackman JA, Zhao Z, Zhdanov VP, Frank CW, Cho NJ

"Vesicle Adhesion and Rupture on Silicon Oxide: Influence of Freeze-Thaw Pretreatment." 

Langmuir 2014; 30(8), 2152-2160.

10

Jackman JA, Choi JH, Zhdanov VP, Cho NJ

"Influence of Osmotic Pressure on Adhesion of Lipid Vesicles to Solid Supports." 

Langmuir 2013; 29(36), 11375-11384.

09

Cho NJ*, Hwang LY, Solandt JJR, Frank CW*

 

(* denotes equal corresponding authors)

"Comparison of Extruded and Sonicated Vesicles for Planar Bilayer Self-Assembly." 

Materials 2013; 6(8), 3294-3308. 

08

Jackman JA, Knoll W, Cho NJ

"Biotechnology Applications of Tethered Lipid Bilayer Membranes." 

Materials 2012; 5(12), 2637-2657. 

06

Claesson M, Cho NJ, Frank CW, Andersson M

"Vesicle Adsorption on Mesoporous Silica and Titania." 

Langmuir 2010; 26(22), 16630-16633.

05

Cho NJ, Frank CW

"Fabrication of a Planar Zwitterionic Lipid Bilayer on Titanium Oxide." 

Langmuir 2010; 26(20),15706-15710.

04

Cho NJ, Frank CW, Kasemo B, Höök F

"Quartz Crystal Microbalance with Dissipation Monitoring of Supported Lipid Bilayers on Various Substrates." 

Nature Protocols; 5(6), 1096-1106.

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