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Lipid Nanoparticles (LNPs)

Artificial Cell, Lipid Nanoparticles (LNPs)
"ProtoCell Concept"

Nanoscale self-assembly is imperative in the fabrication of lipid nanoparticles (LNPs). We leverage artificial intelligence (AI) to select lipid compositions that confer LNPs with dual-functionality, which are capable of in vivo targeted delivery of active functional molecules with reduced toxicity effects while offering protection and stabilization to the active functional molecules.



Tae H, Park S, Tan LY, Yang C, Lee YA, Choe YH, Wüstefeld T, Jung S*, and Cho NJ*

"Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems" 

ACS Nano 2024. (April 19, 2024)


Sut TN,  Park S, Jackman JA**, Cho NJ** 

(** denotes equal corresponding authors)

"Controlling molecular self-assembly of inverse-phosphocholine lipids at oxide interfaces with divalent cations" 

Applied Materials Today 35 (2023) 101953


Hyeonjin Park, Tun Naw Sut, Bo Kyeong Yoon, Vladimir P. Zhdanov, Nam-Joon Cho*, and Joshua A. Jackman*

"Unraveling How Cholesterol Affects Multivalency-Induced Membrane Deformation of Sub-100 nm Lipid Vesicles" 

Langmuir, 2022.


Sut TN, Ferhan AR, Park S, Koo DJ, Yoon BK, Jackman JA*, and Cho NJ*

"Modulating noncovalent and covalent forces to control inverse phosphocholine lipid self-assembly on inorganic surfaces: Nanoarchitectonic design principles." 

Applied Materials Today, 2022, 29: 101618.


Ferhan AR, Park S, Park H, Tae H, Jackman JA*, Cho NJ* 

"Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective.

Advanced Functional Materials, 2022: 2203669.


Park H, Sut TN, Yoon BK, Zhdanov VP, Kim JW, Cho NJ*, Jackman JA*

"Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects.

The Journal of Physical Chemistry Letters, 2022, 13: 1480-1488.


Sut TN, Yoon BK, Jeon WY, Jackman JA*, Cho NJ*

(* denotes equal corresponding authors)

"Supported Lipid Bilayer Coatings: Fabrication, Bioconjugation, and Diagnostic Applications." 

Applied Materials Today, 2021, 25: 101183.


 Tan JYB*, Yoon BK*, Cho NJ, Lovrić J, Jug M, Jackman JA

(* denotes equal first authors)

"Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides.

International Journal of Molecular Sciences, 2021, 22(18): 9664.


Yoon BK, Sut TN, Yoo KY, Lee SH, Hwang Y, Jackman JA*, Cho NJ*

(* denotes equal corresponding authors)

"Lipid Bilayer Coatings for Rapid Enzyme-Linked Immunosorbent Assay.

Applied Materials Today 2021, 24: 101128. 


Park H*, Sut TN*, Yoon BK, Zhdanov VP, Cho NJ**, Jackman JA**

(* denotes equal first authors, ** denotes equal corresponding authors)

"Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles.

Journal of Physical Chemistry Letters, 2021, 12: 6722-6729.



Jackman JA, Cho NJ

"Supported Lipid Bilayer Formation: Beyond Vesicle Fusion." 

Langmuir 2020; 36, 6,1387-1400.



Ho JCS, Steininger C, Hiew SH, Kim MC, Reimhult E, Miserez A, Cho NJ, Parikh AN, Liedberg B


Cover Illustration

"Minimal Reconstitution of Membranous Web Induced by a Vesicle-Peptide Sol-Gel Transition." 

Biomacromolecules 2019; 20, 4, 1709-1718.


Emilsson G, Röder E, Malekian B, Xiong K, Tsai FC, Cho NJ, Bally M, Dahlin A

"Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature."

Frontiers in Chemistry 2019; 7(1), 1-8.


Ferhan AR, Špačková B, Jackman JA, Ma GJ, Sut TN, Homola J, Cho NJ

"Nanoplasmonic Ruler for Measuring Separation Distance Between Supported Lipid Bilayer and Oxide Surfaces." 

Analytical Chemistry 2018; 90(21), 12503-12511.


Ferhan AR, Jackman JA, Malekian B, Xiong K, Emilsson G, Park S, Dahlin AB, Cho NJ

"Nanoplasmonic Sensing Architectures for Decoding Membrane Curvature-Dependent Biomacromolecular Interactions." 

Analytical Chemistry 2018; 90(12), 7458-7466.


Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ

"Interfacial Forces Dictate Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces."

Langmuir 2018; 34(4), 1775-1782.


Gillissen JJ, Jackman JA, Tabaei SR, Cho NJ

"A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response." 

Analytical Chemistry 2018; 90(3), 2238-2245.


Gillissen JJ*, Tabaei SR*, Jackman JA, Cho NJ


(* denotes equal first authors)

"Effect of Glucose on the Mobility of Membrane-Adhering Liposomes." 

Langmuir 2018; 34(1), 503-511.


Gillissen JJ, Jackman JA, Tabaei SR, Yoon BK, Cho NJ

"Quartz Crystal Microbalance Model for Quantitatively Probing the Deformation of Adsorbed Particles at Low Surface Coverage." 

Analytical Chemistry 2017; 89(21), 11711-11718.


Gillissen JJ, Tabaei SR, Jackman JA, Cho NJ


Cover Illustration

"A Model Derived from Hydrodynamic Simulations for Extracting the Size of Spherical Particles from the Quartz Crystal Microbalance." 

Analyst 2017: 142(18), 3370-3379.


Ferhan AR, Ma GJ, Jackman JA, Sut TN, Park JH, Cho NJ

"Probing the Interaction of Dielectric Nanoparticles with Supported Lipid Membrane Coatings on Nanoplasmonic Arrays." 

Sensors 2017; 17(7), 1484.


Jackman JA, Yorulmaz Avsar S, Ferhan AR, Li D, Park JH, Zhdanov VP, Cho NJ

"Quantitative Profiling of Nanoscale Liposome Deformation by a Localized Surface Plasmon Resonance Sensor." 

Analytical Chemistry 2017: 89(2), 1102-1109.


Tabaei SR, Gillissen JJ, Vafaei S, Groves JT, Cho NJ

"Size-Dependent, Stochastic Nature of Lipid Exchange Between Nano-Vesicles and Model Membranes." 

Nanoscale 2016; 8(27), 13513-13520.


Dacic M*, Jackman JA*, Yorulmaz S, Zhdanov VP, Kasemo B, Cho NJ


(* denotes equal first authors)

"Influence of Divalent Cations on Deformation and Rupture of Adsorbed Lipid Vesicles." 

Langmuir 2016; 32(25), 6486-6495. 


Tabaei SR, Gillissen JJ Kim MC, Ho JCS, Liedberg B, Parikh AN, Cho NJ

"Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity." 

Langmuir 2016; 32(21). 5445-5450.


Jackman JA, Kim MC, Zhdanov VP, Cho NJ

"Relationship between Vesicle Size and Steric Hindrance Influences Vesicle Rupture on Solid Supports." 

Physical Chemistry Chemical Physics 2016; 18(4), 3065-3072.


Kim MC, Gunnarsson A, Tabaei SR, Höök F, Cho NJ

"Supported Lipid Bilayer Repair Mediated by AH Peptide." 

Physical Chemistry Chemical Physics 2016; 18(4), 3040-3047.


Jackman JA, Špačková B, Linardy E, Kim MC, Yoon BK, Homola J, Cho NJ


Cover Illustration

"Nanoplasmonic Ruler to Measure Lipid Vesicle Deformation." 

Chemical Communications 2016; 52(1), 76-79. 


Jeong JH, Choi JH, Kim MC, Park JH, Herrin JS, Kim SH, Lee H, Cho NJ

"Elucidating How Bamboo Salt Interacts with Supported Lipid Membranes: Influence of Alkalinity on Membrane Fluidity." 

European Biophysics Journal 2015; 44(5), 383-391.


Tabaei SR, Cho NJ


Cover Illustration

"Lamellar Sheet Exfoliation of Single Lipid Vesicles by a Membrane-Active Peptide." 

Chemical Communications 2015; 51(51), 10272-10275. 


Oh EK*, Jackman JA*, Yorulmaz S, Zhdanov VP, Lee H, Cho NJ


(* denotes equal corresponding authors)

"Contribution of Temperature to Deformation of Adsorbed Vesicles Studied by Nanoplasmonic Biosensing." 

Langmuir 2014; 31(2), 771–781. 


Wallin M, Choi JH, Kim SO, Cho NJ, Andersson M

"Peptide‑induced Formation of a Tethered Lipid Bilayer Membrane on Mesoporous Silica." 

European Biophysics Journal 2015; 44(1-2), 27-36.


Goh HZ*, Jackman JA*, Kim SO, Cho NJ

Cover Illustration

(* denotes equal first authors)

"Controlling Lipid Membrane Architecture for Tunable Nanoplasmonic Biosensing." 

Small 2014; 10(23), 4828-4832. 


Jackman JA, Goh HZ, Zhao Z, Cho NJ

"Contribution of the Hydration Force to Vesicle Adhesion on Titanium Oxide." 

Langmuir 2014; 30(19), 5368–5372.


Goh HZ*, Jackman JA*, Cho NJ


(* denotes equal first authors)

"AH Peptide-Mediated Formation of Charged Planar Lipid Bilayers." 

The Journal of Physical Chemistry B 2014; 118(13), 3616-3621.


Jackman JA, Zhao Z, Zhdanov VP, Frank CW, Cho NJ

"Vesicle Adhesion and Rupture on Silicon Oxide: Influence of Freeze-Thaw Pretreatment." 

Langmuir 2014; 30(8), 2152-2160.


Jackman JA, Choi JH, Zhdanov VP, Cho NJ

"Influence of Osmotic Pressure on Adhesion of Lipid Vesicles to Solid Supports." 

Langmuir 2013; 29(36), 11375-11384.


Cho NJ*, Hwang LY, Solandt JJR, Frank CW*


(* denotes equal corresponding authors)

"Comparison of Extruded and Sonicated Vesicles for Planar Bilayer Self-Assembly." 

Materials 2013; 6(8), 3294-3308. 


Jackman JA, Knoll W, Cho NJ

"Biotechnology Applications of Tethered Lipid Bilayer Membranes." 

Materials 2012; 5(12), 2637-2657. 


Claesson M, Cho NJ, Frank CW, Andersson M

"Vesicle Adsorption on Mesoporous Silica and Titania." 

Langmuir 2010; 26(22), 16630-16633.


Cho NJ, Frank CW

"Fabrication of a Planar Zwitterionic Lipid Bilayer on Titanium Oxide." 

Langmuir 2010; 26(20),15706-15710.


Cho NJ, Frank CW, Kasemo B, Höök F

"Quartz Crystal Microbalance with Dissipation Monitoring of Supported Lipid Bilayers on Various Substrates." 

Nature Protocols; 5(6), 1096-1106.

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