Artificial Cell, Vesicle: "ProtoCell Concept"

The development of simplified model systems that mimic important properties of biological membranes can lead to a clearer understanding of membrane-associated biological processes. At the heart of such systems is the lipid vesicle, which can either be used intact to model curved biological membranes or to form supported lipid bilayers.


Jackman JA, Cho NJ

"Supported Lipid Bilayer Formation: Beyond Vesicle Fusion."

Langmuir 2020; 36, 6,1387-1400.


Ho JCS, Steininger C, Hiew SH, Kim MC, Reimhult E, Miserez A, Cho NJ, Parikh AN, Liedberg B

 Cover Illustration 

"Minimal Reconstitution of Membranous Web Induced by a Vesicle-Peptide Sol-Gel Transition."

Biomacromolecules 2019; 20, 4, 1709-1718.



Emilsson G, Röder E, Malekian B, Xiong K, Tsai FC, Cho NJ, Bally M, Dahlin A


Ferhan AR, Špačková B, Jackman JA, Ma GJ, Sut TN, Homola J, Cho NJ

"Nanoplasmonic Ruler for Measuring Separation Distance Between Supported Lipid Bilayer and Oxide Surfaces."

Analytical Chemistry 2018; 90(21), 12503-12511.


Biswas K, Cho NJ, Groves JT

"Fabrication of Multicomponent, Spatially Segregated DNA and Protein-Functionalized Supported Membrane Microarray."

Langmuir 2018; 34(33), 9781-9788.



Meker S, Chin HK, Sut TN, Cho NJ

"Amyloid-β Peptide Triggers Membrane Remodeling in Supported Lipid Bilayers Depending on Their Hydrophobic Thickness."

Langmuir 2018; 34(32), 9548-9560.

Supporting Information


Ferhan AR, Jackman JA, Malekian B, Xiong K, Emilsson G, Park S, Dahlin AB, Cho NJ

"Nanoplasmonic Sensing Architectures for Decoding Membrane Curvature-Dependent Biomacromolecular Interactions."

Analytical Chemistry 2018; 90(12), 7458-7466.


Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ

"Interfacial Forces Dictate Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces."

Langmuir 2018; 34(4), 1775-1782.


Gillissen JJ, Jackman JA, Tabaei SR, Cho NJ

"A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response."

Analytical Chemistry 2018; 90(3), 2238-2245.

Supporting Information


Gillissen JJ*, Tabaei SR*, Jackman JA, Cho NJ

(* denotes equal first authors)

"Effect of Glucose on the Mobility of Membrane-Adhering Liposomes."

Langmuir 2018; 34(1), 503-511.


Gillissen JJ, Jackman JA, Tabaei SR, Yoon BK, Cho NJ

"Quartz Crystal Microbalance Model for Quantitatively Probing the Deformation of Adsorbed Particles at Low Surface Coverage."

Analytical Chemistry 2017; 89(21), 11711-11718.

Supporting Information


Gillissen JJ, Tabaei SR, Jackman JA, Cho NJ

 Cover Illustration 

"A Model Derived from Hydrodynamic Simulations for Extracting the Size of Spherical Particles from the Quartz Crystal Microbalance."

Analyst 2017: 142(18), 3370-3379.

Supporting Information


Ferhan AR, Ma GJ, Jackman JA, Sut TN, Park JH, Cho NJ

"Probing the Interaction of Dielectric Nanoparticles with Supported Lipid Membrane Coatings on Nanoplasmonic Arrays."

Sensors 2017; 17(7), 1484.

Supporting Information


Ferhan AR, Jackman JA, Cho NJ

"Probing Spatial Proximity of Supported Lipid Bilayers to Silica Surfaces by Localized Surface Plasmon Resonance Sensing."

Analytical Chemistry 2017: 89(7), 4301-4308.

Supporting Information


Ferhan AR, Jackman JA, Cho NJ

"Investigating How Vesicle Size Influences Vesicle Adsorption on Titanium Oxide: A Competition between Steric Packing and Shape Deformation." 

Physical Chemistry Chemical Physics 2017: 19(3), 2131-2139.

Supporting Information


Jackman JA, Yorulmaz Avsar S, Ferhan AR, Li D, Park JH, Zhdanov VP, Cho NJ

"Quantitative Profiling of Nanoscale Liposome Deformation by a Localized Surface Plasmon Resonance Sensor." 

Analytical Chemistry 2017: 89(2), 1102-1109.


Ferhan AR, Jackman JA, Cho NJ

"Integration of Quartz Crystal Microbalance-Dissipation and Reflection-Mode Localized Surface Plasmon Resonance Sensors for Biomacromolecular Interaction Analysis." 

Analytical Chemistry 2016: 88(24), 12524-12531.

Supporting Information


Tabaei SR, Gillissen JJ, Cho NJ

 Cover Illustration 

"Probing Membrane Viscosity and Inter-Leaflet Friction of Supported Lipid Bilayers by Tracking Electrostatically Adsorbed, Nano-Sized Vesicles." 

Small 2016; 12, 6338–6344.

Supporting Information


Tabaei SR, Gillissen JJ, Block S, Hook F, Cho NJ

"Hydrodynamic Propulsion of Liposomes Electrostatically Attracted to a Lipid Membrane Reveals Size-Dependent Conformational Changes." 

ACS Nano 2016; 10(9), 8812-8820.

Supporting Information


Tabaei SR, Gillissen JJ, Vafaei S, Groves JT, Cho NJ

"Size-Dependent, Stochastic Nature of Lipid Exchange Between Nano-Vesicles and Model Membranes." 

Nanoscale 2016; 8(27), 13513-13520.

Supporting Information


Dacic M*, Jackman JA*, Yorulmaz S, Zhdanov VP, Kasemo B, Cho NJ

(* denotes equal first authors)

"Influence of Divalent Cations on Deformation and Rupture of Adsorbed Lipid Vesicles." 

Langmuir 2016; 32(25), 6486-6495. 

Supporting Information


Tabaei SR, Gillissen JJ Kim MC, Ho JCS, Liedberg B, Parikh AN, Cho NJ

"Brownian Dynamics of Electrostatically Adhering Small Vesicles to a Membrane Surface Induces Domains and Probes Viscosity." 

Langmuir 2016; 32(21). 5445-5450.

Supporting Information


Jackman JA, Kim MC, Zhdanov VP, Cho NJ

"Relationship between Vesicle Size and Steric Hindrance Influences Vesicle Rupture on Solid Supports."

Physical Chemistry Chemical Physics 2016; 18(4), 3065-3072.

Supporting Information


Kim MC, Gunnarsson A, Tabaei SR, Höök F, Cho NJ

"Supported Lipid Bilayer Repair Mediated by AH Peptide."

Physical Chemistry Chemical Physics 2016; 18(4), 3040-3047.

Supporting Information


Jackman JA, Špačková B, Linardy E, Kim MC, Yoon BK, Homola J, Cho NJ

 Cover Illustration 

"Nanoplasmonic Ruler to Measure Lipid Vesicle Deformation." 

Chemical Communications 2016; 52(1), 76-79. 

Supporting Information


Jeong JH, Choi JH, Kim MC, Park JH, Herrin JS, Kim SH, Lee H, Cho NJ

"Elucidating How Bamboo Salt Interacts with Supported Lipid Membranes: Influence of Alkalinity on Membrane Fluidity." 

European Biophysics Journal 2015; 44(5), 383-391.


Tabaei SR, Cho NJ

 Cover Illustration 

"Lamellar Sheet Exfoliation of Single Lipid Vesicles by a Membrane-Active Peptide." 

Chemical Communications 2015; 51(51), 10272-10275. 

Supporting Information


Oh EK*, Jackman JA*, Yorulmaz S, Zhdanov VP, Lee H, Cho NJ

(* denotes equal corresponding authors) 

"Contribution of Temperature to Deformation of Adsorbed Vesicles Studied by Nanoplasmonic Biosensing." 

Langmuir 2014; 31(2), 771–781. 


Wallin M, Choi JH, Kim SO, Cho NJ, Andersson M

"Peptide‑induced Formation of a Tethered Lipid Bilayer Membrane on Mesoporous Silica." 

European Biophysics Journal 2015; 44(1-2), 27-36.


Jackman JA, Zhdanov VP, Cho NJ

"Nanoplasmonic Biosensing for Soft Matter Adsorption: Kinetics of Lipid Vesicle Attachment and Shape Deformation." 

Langmuir 2014; 30(31), 9494–9503.


Goh HZ*, Jackman JA*, Kim SO, Cho NJ

(* denotes equal contribution)

 Cover Illustration 

"Controlling Lipid Membrane Architecture for Tunable Nanoplasmonic Biosensing." 

Small 2014; 10(23), 4828-4832. 

Supporting Information


Goh HZ, Cho NJ

"Rupture of Zwitterionic Lipid Vesicles by an Amphipathic, α-Helical Peptide: Indirect Effects of Sensor Surface and Implications for Experimental Analysis." 

Colloids and Surfaces B: Biointerfaces 2014: 121, 340-346.


Jackman JA, Goh HZ, Zhao Z, Cho NJ

"Contribution of the Hydration Force to Vesicle Adhesion on Titanium Oxide."

Langmuir 2014; 30(19), 5368–5372.

Supporting Information


Goh HZ*, Jackman JA*, Cho NJ

(* denotes equal contribution)

"AH Peptide-Mediated Formation of Charged Planar Lipid Bilayers." 

The Journal of Physical Chemistry B 2014; 118(13), 3616-3621


Jackman JA, Zhao Z, Zhdanov VP, Frank CW, Cho NJ

"Vesicle Adhesion and Rupture on Silicon Oxide: Influence of Freeze-Thaw Pretreatment." 

Langmuir 2014; 30(8), 2152-2160.


Jackman JA, Choi JH, Zhdanov VP, Cho NJ

"Influence of osmotic pressure on adhesion of lipid vesicles to solid supports." 

Langmuir 2013; 29(36), 11375-11384.


Cho NJ*, Hwang LY, Solandt JJR, Frank CW*

(* denotes equal corresponding authors)

"Comparison of Extruded and Sonicated Vesicles for Planar Bilayer Self-Assembly."

Materials 2013; 6(8), 3294-3308. 


Jackman JA, Knoll W, Cho NJ

"Biotechnology Applications of Tethered Lipid Bilayer Membranes." 

Materials 2012; 5(12), 2637-2657. 


Cho NJ, Jackman JA, Liu M, Frank CW

"pH-Driven Assembly of Various Supported Lipid Platforms: A Comparative Study on Silicon Oxide and Titanium Oxide." 

Langmuir 2011; 27(7), 3739-3748.

Supporting Information


Claesson M, Cho NJ, Frank CW, Andersson M

"Vesicle Adsorption on Mesoporous Silica and Titania." 

Langmuir 2010; 26(22), 16630-16633.

Supporting Information


Cho NJ, Frank CW

"Fabrication of a Planar Zwitterionic Lipid Bilayer on Titanium Oxide." 

Langmuir 2010; 26(20),15706-15710.

Supporting Information


Cho NJ, Frank CW, Kasemo B, Höök F