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Solvent-assisted Lipid Bilayer (SALB)

"Simple is the Best"

We have developed a new platform technology known as the solvent-assisted lipid bilayer (SALB) method to fabricate supported lipid bilayers. It is based on lipid self-assembly upon exchange from organic to aqueous solvent. The approach is quick, easy to implement, and compatible with a wide range of lipid compositions and material supports.



Hyeonjin Park, Sut TN, Ferhan AR, Yoon BK, Zhdanov VP, Cho NJ*, and Jackman JA*

(* denotes equal coauthors, ** denotes equal corresponding authors)

"pH-Modulated Nanoarchitectonics for Enhancement of Multivalency-Induced Vesicle Shape Deformation at Receptor-Presenting Lipid Membrane Interfaces"  

Langmuir 2023


Tae, HyunHyuk; Yang, Chungmo; Cho, Nam-Joon

(* denotes equal coauthors, ** denotes equal corresponding authors)

"Artificial Cell Membrane Platforms by Solvent-Assisted Lipid Bilayer (SALB) Formation."  

Accounts of Materials Research


Sut TN*, Tan SW*, Jeon WY, Yoon BK**, Cho NJ**, Jackman JA**

(* denotes equal coauthors, ** denotes equal corresponding authors)

"Streamlined Fabrication of Hybrid Lipid Bilayer Membranes on Titanium Oxide Surfaces: A Comparison of One- and Two-Tail SAM Molecules."  

Nanomaterials, 2022, 12 (7): 1153.


Meker S, Halevi O, Chin H, Sut TN, Jackman JA, Tan EL, Potroz MG, Cho NJ

"Inkjet-Printed Phospholipid Bilayers on Titanium Oxide Surfaces: Towards Functional Membrane Biointerfaces." 

Membranes, 2022, 12 (4): 361


Xu H, Tae H, Cho NJ*, Huang C*, Hsia KJ*

(* denotes equal corresponding authors)

"Thermodynamic Modeling of Solvent-Assisted Lipid Bilayer Formation Process." 

Micromachines, 2022, 13(1): 134.


Ma GJ, Yoon BK, Sut TN, Yoo KY, Lee SH, Jeon WY, Jackman JA*, Ariga K*, Cho NJ*

(* denotes equal corresponding authors)

"Lipid Coating Technology: A Potential Solution to Address the Problem of Sticky Containers and Vanishing Drugs.

View, 2021: 20200078.


Jackman JA, Cho NJ


"Supported Lipid Bilayer Formation: Beyond Vesicle Fusion." 

Langmuir 2020; 36 (6),1387-1400.


Ferhan AR, Yoon BK, Park S, Sut TN, Chin H, Park JH, Jackman JA, Cho NJ

"Solvent-Assisted Preparation of Supported Lipid Bilayers." 

Nature Protocols 2019; 14, 2091–2118.


Guo JJ, Ho JCS, Chin H, Mark AE, Zhou C, Kjellenberg S, Liedberg B, Parikh A, Hinks J, Cho NJ, Mu Y, Seviour TW


"Response of Microbial Membranes to Butanol: Interdigitation Vs. Disorder." 

Physical Chemistry Chemical Physics  2019; 21, 11903-11915.


Maekawa T*, Chin H*, Nyu T, Sut TN, Ferhan AR, Hayashi T, Cho NJ


(* denotes equal first authors)

"Molecular Diffusion and Nano-Mechanical Properties of Multi-Phase Supported Lipid Bilayers." 

Physical Chemistry Chemical Physics 2019; 21,16686-16693.


Mori T, Chin H, Kawashima K, Ngo H, Cho NJ, Nakanishi W, Hill J, Ariga K


"Dynamic Control of Intramolecular Rotation by Tuning the Surrounding 2D Matrix Field." 

ACS Nano 2019; 13(2), 2410–2419.


Wang LL*, Biswas K*, Yoon BK, Kawakami L, Park S, Groves JT, Li L, Huang W, Cho NJ


(* denotes equal first authors)

"Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers." 

Langmuir 2018; 34(36), 10764-10773.


Gillissen JJ, Tabaei SR, Cho NJ


"A Phenomenological Model for the Solvent-Assisted Lipid Bilayer Formation Method." 

Physical Chemistry Chemical Physics 2016; 18(35), 24157-24163.


Tabaei SR, Guo F, Rutaganira F, Vafaei S, Chong I, Shokat K, Glenn JS, Cho NJ


"Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases." 

Analytical Chemistry 2016; 88(10), 5042-5045.


Tabaei SR, Ng WB, Cho SJ, Cho NJ

"Controlling the Formation of Phospholipid Monolayer, Bilayer and Intact Vesicle Layer on Graphene." 

ACS Applied Materials & Interfaces 2016; 8(18), 11875-11880.


Kim MC, Gillissen JJ, Tabaei SR, Zhdanov VP, Cho NJ


"Spatiotemporal Dynamics of Solvent-Assisted Lipid Bilayer Formation." 

Physical Chemistry Chemical Physics 2015; 17(46), 31145-31151.


Tabaei SR, Jackman JA, Kim MC, Yorulmaz S, Vafaei S, Cho NJ


"Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method." 

Journal of Visualized Experiments 2015; (106), e53073.


Tabaei SR, Vafaei S, Cho NJ


"Fabrication of Charged Membranes by the Solvent-Assisted Lipid Bilayer (SALB) Formation Method on SiO2 and Al2O3." 

Physical Chemistry Chemical Physics 2015; 17(46) 11546-11552.


Tabaei SR, Jackman JA, Kim SO, Zhdanov VP, Cho NJ


"Solvent-Assisted Lipid Self-Assembly at Hydrophilic Surfaces: Factors Influencing the Formation of Supported Membranes." 

Langmuir 2015; 31(10), 3125-3134.


Jackman JA, Tabaei SR, Zhao Z, Yorulmaz S, Cho NJ


"Self-Assembly Formation of Lipid Bilayer Coatings on Bare Aluminum Oxide: Overcoming the Force of Interfacial Water." 

ACS Applied Materials & Interfaces 2015; 7(1), 959–968.


Tabaei SR, Jackman JA, Liedberg B, Parikh A, Cho NJ


"Observation of Stripe Superstructure in the β-Two-Phase Coexistence Region of Cholesterol–Phospholipid Mixtures in Supported Membranes." 

Journal of the American Chemical Society 2014; 136(49), 16962–16965.


Tabaei SR, Jackman JA, Kim SO, Liedberg B, Knoll W, Parikh AN, Cho NJ


"Formation of Cholesterol-Rich Supported Membranes Using Solvent-Assisted Lipid Self-Assembly." 

Langmuir 2014; 30(44), 13345–13352.


Tabaei SR, Choi JH, Goh HZ, Zhdanov VP, Cho NJ


"Solvent-Assisted Lipid Bilayer Formation on Silicon Dioxide and Gold." 

Langmuir 2014; 30(34), 10363–10373.

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