Infectious Diseases-Antiviral: “LEAD Strategies”

The engineering strategies developed and employed by our group to study biointerfacial science topics are being adopted to address outstanding needs in molecular virology. Based on engineering frameworks, we have a dedicated research effort on peptide-based antiviral drug development. Another emerging thrust is the creation of functional diagnostics for viral surveillance.


Cho NJ*, Glenn JS*

(* denotes equal corresponding authors)

"Materials Science Approaches in the Development of Broad-Spectrum Antiviral Therapies." 

Nature Materials 2020; DOI: 10.1038/s41563-020-0698-4.


Park S, Yorulmaz Avsar S, Cornell B, Ferhan AR, Jeon WY, Chung M, Cho NJ

 Cover Illustration 

"Probing the influence of tether density on tethered bilayer lipid membrane (tBLM)-peptide interactions." 

Applied Materials Today 2020; 100527.


Park S, Jackman JA, Cho NJ

"Comparing the Membrane Interaction Profiles of Two Antiviral Peptides: Insights into Structure-Function Relationship." 

Langmuir 2019; 35, 30, 9934-9943.

Supporting Information


Park S, Jackman JA, Cho NJ

"Quantitative Accounting of Dye Leakage and Photobleaching in Single Lipid Vesicle Measurements: Implications for Biomacromolecular Interaction Analysis." 

Colloids and Surfaces B: Biointerfaces 2019; 182,110338

Supporting Information


Camargos VN, Foureaux G, Medeiros DC, Silveira VT, Queiroz-Junior CM, Matosinhos ALB, Figueiredo AFA, Sousa CDF, Moreira TP, Queiroz VF, Dias ACF, Santana KTO, Passos I, Real ALCV, Silva LC, Mourão FAG, Wnuk NT, Oliveira MAP, Macari S, Silva T, Garlet GP, Jackman JA, Soriani FM, Moraes MFD, Mendes EMAM, Robeiro FM, Costa GMJ, Teixeira AL, Cho NJ, Oliveira ACP, Teixeira MM, Costa VV, Souza DG

"In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody-dependent enhancement and an antiviral peptide therapy."

EBioMedicine 2019; 44, 516-529.


Park S, Jackman JA, Xu XB, Weiss PS, Cho NJ

"Micropatterned Viral Membrane Clusters for Antiviral Drug Evaluation."

ACS Applied Materials & Interfaces 2019; 11 (15), 13984–13990.


Jackman JA, Shi PY, Cho NJ

"Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy."

ACS Infectious Diseases 2019; 5(1), 4-8.



Jackman JA, Costa VV, Park S, Real ALCV, Park JH, Cardozo PL, Ferhan AR, Olmo IG, Poreira TP, Bambirra JL, Queiroz VF, Queiroz-Junior CM, Foureaux G, Souza DG, Ribeiro FM, Yoon BK, Wynendaele E, De Spiegeleer B, Teixeira MM, Cho NJ

"Therapeutic Treatment of Zika Virus Infection Using a Brain-Penetrating Antiviral Peptide."

Nature Materials 2018; 17, 971–977.


Jackman JA, Cho NJ

"Targeting the Achilles Heel of Zika Virus and Other Emerging Viral Pathogens." 

Advanced Therapeutics 2018; 1(5), 1800045.



Beldar S, Manimekalai MSS, Cho NJ, Baek KH, Gruber G, Yoon HS

"Self-Association and Conformational Variation of NS5A Domain 1 of Hepatitis C Virus."

Journal of General Virology 2018; 99(2), 194-208.

Supporting Information


Nasir MZM, Jackman JA, Cho NJ, Ambrosi A, Pumera M

"Detection of Amphipathic Viral Peptide on Screen-Printed Electrodes by Liposome Rupture Impact Voltammetry."

Analytical Chemistry 2017; 89(21), 11753-11757.


Kim SO*, Jackman JA*, Elazar M, Cho SJ, Glenn JS**, Cho NJ**

(* denotes equal first authors; ** denotes equal corresponding authors)

"Quantitative Evaluation of Viral Protein Binding to Phosphoinositide Receptors and Pharmacological Inhibition."

Analytical Chemistry 2017; 89(18), 9742-9750.


Cho NJ, Pham EA, Hagey RJ, Leveque VJ, Ma H, Klumpp K, Glenn JS

Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer. 

ACS Central Science 2016; 2(7), 456-466.

Supporting Information


Jackman JA, Linardy E, Yoo DH, Seo JE, Ng WB, Klemme D, Wittenberg N, Oh SH, Cho NJ

"Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles towards Virucidal Drug Evaluation."

Small 2016; 12(9), 1159-1166.


Jackman JA, Lee JW, Cho NJ

"Nanomedicine for Infectious Disease Applications: Innovation towards Broad-Spectrum Treatment of Viral Infections." 

Small 2016; 12(9), 1133-1139.


Jackman JA, Goh HZ, Zhdanov VP, Knoll W, Cho NJ

"Deciphering How Pore Formation Causes Strain-Induced Membrane Lysis of Lipid Vesicles." 

Journal of the American Chemical Society 2016; 138(4), 1406-1413.

Supporting Information


Hanson JM, Gettel DL, Tabaei SR, Jackman JA, Kim MC, Sasaki DY, Liedberg B, Groves JT, Cho NJ*, Parikh AN*

(* denotes equal corresponding authors)

"Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide." 

Biophysical Journal 2016; 110(1), 176-187. 

Supporting Information


Amaravadhi H, Li E, Lee JJ, Cho NJ, Yoon HS

"Combination of Pharmacophore Hypothesis and Molecular Docking to Identify Novel Inhibitors Targeting Thumb Site II of HCV NS5B Polymerase." 

Molecular Diversity 2015; 19(3) 529-539.


Jackman JA, Saravanan R, Zhang Y, Tabaei SR, Cho NJ

 Cover Illustration 

"Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides."

Small 2014; 11(20), 2372-2379.

Supporting Information


Cho NJ, Lee CH, Pang PS, Sklan EH, Koytak ES, Kay CK, Kanazawa KK, Frank CW, Glenn JS

""Phosphatidylinositol 4,5-Bisphosphate is an HCV NS5A Ligand and Mediates Replication of the Viral Genome." " 

Gastroenterology 2015; 148(3), 616-625.

Supporting Information


Jackman JA, Goh HZ, Zhdanov VP, Cho NJ

"Rupture of Lipid Vesicles by a Broad-Spectrum Antiviral Peptide: Influence of Vesicle Size." 

Journal of Physical Chemistry B 2013; 117(50), 16117-16128.

Supporting Information


Tabaei SR, Rabe M, Zhdanov VP, Cho NJ*, Höök F*

(* denotes equal corresponding authors.)

"Single Vesicle Analysis Reveals Nanoscale Membrane Curvature Selective Pore Formation in Lipid Membranes by an Antiviral α-Helical Peptide." 

Nano Letters 2012; 2(11), 5719-5725. 

Supporting Information


Jackman JA, Cho NJ

"Model Membrane Platforms for Biomedicine: Case Study on Antiviral Drug Development."

Biointerphases 2012; 7(18), 1-20.


Cho NJ, Dvory-Sobol H, Lee CH, Cho SJ, Glenn JS

"Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B." 

Science Translational Medicine 2010; 2(15), 15ra6.


Bryson PD, Cho NJ, Einav S, Lee CH, Tai V, Bechtel J, Sivaraja M, Roberts C, Schmitz U, Glenn JS

"A Small Molecule Inhibits HCV Replication and Alters NS4B's Subcellular Distribution." 

Antiviral Research 2010; 87(1), 1-8.


Cho NJ, Dvory-Sobol H, Xiong A, Frank CW, Glenn JS

"Mechanism of an Amphipathic α-Helical Peptide’s Antiviral Activity Involves Size-Dependent Virus Particle Lysis." 

ACS Chemical Biology 2009; 4(12), 1061-1067.

Supporting Information


Cho NJ, Elazar M, Xiong A, Lee WJ, Chiao E, Baker EJ, Frank CW, Glenn JS

"Viral Infection of Human Progenitor and Liver-Derived Cells Encapsulated in Three-Dimensional PEG-based Hydrogel." 

Biomedical Materials 2009; 4(1), 011001.

Supporting Information


Cho NJ, Cho SJ, Cheong KH, Glenn JS, Frank CW

"Employing an Amphipathic Viral Peptide to Create a Lipid Bilayer on Au and TiO2." 

Journal of the American Chemical Society 2007; 129(33), 10050-10051.