Translational Materials Innovation Group

Bicelle: "Fundamental to Translational Science"

This highly versatile approach to fabricate high-quality supported lipid bilayers involves the deposition of quasi-two-dimensional lamellar, bicellar disks that are composed of a mixture of long-chain and short-chain phospholipids. We explore the use of bicellar mixtures as tools for model membrane fabrication and study mechanistic details behind the bicelle-mediated bilayer fabrication process.


Sut TN*, Valle-González ER*, Yoon BK*, Park S, Jackman JA**, Cho NJ**

(* denotes equal first authors, ** denotes equal corresponding authors)

"Engineered Lipid Bicelle Nanostructures for Membrane-Disruptive Antibacterial Applications.

Applied Materials Today 2021, 22: p. 100947.


Park S, Sut TN, Ma GJ, Parikh A, Cho NJ

"Crystallization of Cholesterol in Phospholipid Membranes Follows Ostwald's Rule of Stages." 

Journal of the American Chemical Society 2020, 142 (52), 21872-21882


Belling JN, Heidenreich LK, Park JH, Kawakami LM, Takahashi J, Frost IM, Gong Y, Young TD, Jackman JA, Jonas SJ*, Cho NJ*, Weiss PS*


(* denotes equal corresponding authors)

"Lipid-Bicelle-Coated Microfluidics for Intracellular Delivery with Reduced Fouling." 

Applied  Materials & Interfaces 2020; 12, 45744-45752.


Sut TN, Yoon BK, Park S, Jackman JA*, Cho NJ*


(* denotes equal corresponding authors)

"Versatile Formation of Supported Lipid Bilayers from Bicellar Mixtures of Phospholipids and Capric Acid." 

Scientific Reports 2020; 10, 13849.


Sut TN, Park S, Yoon BK, Jackman JA*, Cho NJ*


(* denotes equal corresponding authors)

"Optimal Formation of Uniform-Phase Supported Lipid Bilayers from Phospholipid-Monoglyceride Bicellar Mixtures." 

Journal of Industrial and Engineering Chemistry 2020; 88, 285-291.


Sut TN, Park S, Yoon BK, Jackman JA*, Cho NJ*


(* denotes equal corresponding authors)

"Supported Lipid Bilayer Formation from Phospholipid-Fatty Acid Bicellar Mixtures." 

Langmuir 2020; 36, 5021-5029.


Belling JN, Cheung KM, Jackman JA, Sut TN, Allen M, Park JH, Jonas SJ, Cho NJ*, Weiss PS*


(* denotes equal corresponding authors)

"Lipid Bicelle Micropatterning Using Chemical Lift-Off Lithography." 

ACS Applied Materials & Interfaces 2020; 12, 11, 13447-13455.


Sut TN, Park S, Choe Y, Cho NJ


Cover Illustration

"Characterizing the Supported Lipid Membrane Formation from Cholesterol-Rich Bicelles." 

Langmuir 2019; 35, 15063-15070.


Sut TN, Jackman JA, Yoon BK, Park S, Kolahdouzan K, Ma G, Zhdanov V, Cho NJ

"Influence of NaCl Concentration on Bicelle-Mediated SLB Formation." 

Langmuir 2019; 35, 32, 10658-10666.


Kolahdouzan K*, Jackman JA*, Yoon BK, Kim MC, Johal MS, Cho NJ


(* denotes equal first authors)

"Optimizing the Formation of Supported Lipid Bilayers from Bicellar Mixtures." 

Langmuir 2017; 33(20), 5052-5064.


Nanyang Technological University, Centre for Biomimetic Sensor Science

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