Protein Adsorption: “Molecular-Level Understanding from Fundamental Research”

We adopt a materials engineering approach to understanding how the conformational stability of proteins in solution can impact protein adsorption using state-of-the-art characterization techniques. Our studies are aimed at improving surface passivation along with a wide range of other biological-related applications.


Ma GJ, Ferhan AR, Jackman JA*, Cho NJ*

​(* denotes equal corresponding authors)

"Conformational Flexibility of Fatty Acid-Free Bovine Serum Albumin Proteins Enables Superior Antifouling Coatings." 

Nature Communications Materials 2020; 1, 45.


Tan JYB*, Yoon BK*, Ma GJ, Sut TN, Cho NJ**, Jackman JA**

​​(* denotes equal corresponding authors  ** denotes equal corresponding authors)

"Unraveling How Ethanol-Induced Conformational Changes Affect BSA Protein Adsorption onto Silica Surfaces." 

Langmuir 2020; Accepted.


Ma GJ, Ferhan AR, Sut TN, Jackman JA*, Cho NJ*

​(* denotes equal corresponding authors)

"Understanding How Natural Sequence Variation in Serum Albumin Proteins Affects Conformational Stability and Protein Adsorption." 

Colloids and Surfaces B: Biointerfaces 2020; 194, 111194.


Park JH*, Ferhan AR*, Jackman JA, Cho NJ

(* denotes equal first authors)

"Modulating Conformational Stability of Human Serum Albumin and Implications for Surface Passivation Applications." 

Colloids and Surfaces B: Biointerfaces 2019; 306-312.


Park JH, Jackman JA, Ferhan AR, Ma GJ, Yoon BK, Cho NJ

"Temperature-Induced Denaturation of BSA Protein Molecules for Improved Surface Passivation Coatings."

ACS Applied Materials & Interfaces 2018; 10(38), 32047-32057.


Ferhan AR, Jackman JA, Sut TN, Cho NJ

"Quantitative Comparison of Protein Adsorption and Conformational Changes on Dielectric-Coated Nanoplasmonic Sensing Arrays."

Sensors 2018; 18(4), 1283.


Jackman JA, Ferhan AR, Yoon BK, Park JH, Zhdanov VP, Cho NJ

"Indirect Nanoplasmonic Sensing Platform for Monitoring Temperature-Dependent Protein Adsorption."

Analytical Chemistry 2017; 89(23), 12976-12983.

Supporting Information


Zhang B, Yorulmaz Avsar S, Corliss MK, Chung M, Cho NJ

"Influence of Natural Organic Matter (NOM) Coatings on Nanoparticle Adsorption onto Supported Lipid Bilayers."

Journal of Hazardous Materials 2017; 339, 264-273.


Park JH*, Sut TN*, Jackman JA, Ferhan AR, Yoon BK, Cho NJ

(* denotes equal contribution)

"Controlling Adsorption and Passivation Properties of Bovine Serum Albumin on Silica Surfaces by Ionic Strength Modulation and Cross-Linking."

Physical Chemistry Chemical Physics 2017: 19, 8854-8865.



Belling JN*, Jackman JA*, Yorulmaz Avsar S, Park JH, Wang Y, Potroz MG, Ferhan AR, Weiss PS, Cho NJ

(* denotes equal contribution)

"Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H."

ACS Nano 2016; 10(11), 10161-10172.

Supporting Information


Zhdanov VP, Cho NJ

"Kinetics of Formation of a Protein Corona around Nanoparticles."

Mathematical Biosciences 2016; 282, 82-90.


Lee WJ, Wiseman M, Cho NJ, Glenn JS, Frank CW

"The Reliable Targeting of Specific Drug Release Profiles by Integrating Arrays of Different Albumin-Encapsulated Microsphere Types." 

Biomaterials 2009; 30(34), 6648-6654.

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