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Protein Adsorption

Protein Adsorption
"Molecular-Level Understanding from Fundamental Research"

We adopt a materials engineering approach to understanding how the conformational stability of proteins in solution can impact protein adsorption using state-of-the-art characterization techniques. Our studies are aimed at improving surface passivation along with a wide range of other biological-related applications.

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Ma GJ, Yoon BK, Sut TN, Yoo KY, Lee SH, Jeon WY, Jackman JA*, Ariga K*, Cho NJ* 

(* denotes equal corresponding authors)

"Lipid Coating Technology: A Potential Solution to Address the Problem of Sticky Containers and Vanishing Drugs."

View, 2021: 20200078. 


Yoon BK*, Ma GJ*, Park H, Ferhan AR, Cho NJ**, Jackman JA**

(* denotes equal first authors, ** denotes equal corresponding authors)

"Solvent-induced conformational tuning of lysozyme protein adlayers on silica surfaces: A QCM-D and LSPR study."

International Journal of Biological Macromolecules, 2021, 182: 1906-1914. 


Wynendaele E, Ma GJ, Xu X, Cho NJ*, De Spiegeleer B*

(* denotes equal corresponding authors)

"Conformational stability as a quality attribute for the cell therapy raw material human serum albumin."

RSC Advances, 2021, 11, 15332-15339


Park H, Ma GJ, Yoon BK, Cho NJ*, Jackman JA*

(* denotes equal corresponding authors)

"Comparing Protein Adsorption onto Alumina and Silica Nanomaterial Surfaces: Clues for Vaccine Adjuvant Development."

Langmuir 2021; 37 (3), 1306-1314


Park JH, Jackman JA, Ferhan AR, Belling JN, Mokrzecka N, Weiss PS*, Cho NJ*


(* denotes equal corresponding authors)

"Cloaking Silica nanoparticles with Functional Protein Coating for Reduced Complement Activation and Cellular Uptake."

ACS Nano 2020; 14, 9, 11950-11961.


Ma GJ, Ferhan AR, Jackman JA*, Cho NJ*


(* denotes equal corresponding authors)

"Elucidating How Different Amphipathic Stabilizers Affect BSA Protein Conformational Properties and Adsorption Behavior." 

Langmuir 2020; 36,10606–10614.


Ma GJ, Ferhan AR, Jackman JA*, Cho NJ*


(* denotes equal corresponding authors)

"Conformational Flexibility of Fatty Acid-Free Bovine Serum Albumin Proteins Enables Superior Antifouling Coatings.

Nature Communications Materials 2020; 1, 45.


Tan JYB*, Yoon BK*, Ma GJ, Sut TN, Cho NJ**, Jackman JA**


(* denotes equal first authors  ** denotes equal corresponding authors)

"Unraveling How Ethanol-Induced Conformational Changes Affect BSA Protein Adsorption onto Silica Surfaces." 

Langmuir 2020; 36, 9215-9224.


Ma GJ, Ferhan AR, Sut TN, Jackman JA*, Cho NJ*


Cover Illustration

(* denotes equal corresponding authors)

"Understanding How Natural Sequence Variation in Serum Albumin Proteins Affects Conformational Stability and Protein Adsorption." 

Colloids and Surfaces B: Biointerfaces 2020; 194, 111194.


Park JH*, Ferhan AR*, Jackman JA, Cho NJ


(* denotes equal first authors)

"Modulating Conformational Stability of Human Serum Albumin and Implications for Surface Passivation Applications." 

Colloids and Surfaces B: Biointerfaces 2019; 306-312.​


Park JH, Jackman JA, Ferhan AR, Ma GJ, Yoon BK, Cho NJ

"Temperature-Induced Denaturation of BSA Protein Molecules for Improved Surface Passivation Coatings." 

ACS Applied Materials & Interfaces 2018; 10(38), 32047-32057.


Jackman JA, Ferhan AR, Yoon BK, Park JH, Zhdanov VP, Cho NJ

"Indirect Nanoplasmonic Sensing Platform for Monitoring Temperature-Dependent Protein Adsorption." 

Analytical Chemistry 2017; 89(23), 12976-12983.


Zhang B, Yorulmaz Avsar S, Corliss MK, Chung M, Cho NJ

"Influence of Natural Organic Matter (NOM) Coatings on Nanoparticle Adsorption onto Supported Lipid Bilayers." 

Journal of Hazardous Materials 2017; 339, 264-273.


Park JH*, Sut TN*, Jackman JA, Ferhan AR, Yoon BK, Cho NJ


(* denotes equal first authors)

"Controlling Adsorption and Passivation Properties of Bovine Serum Albumin on Silica Surfaces by Ionic Strength Modulation and Cross-Linking." 

Physical Chemistry Chemical Physics 2017: 19, 8854-8865.


Belling JN*, Jackman JA*, Yorulmaz Avsar S, Park JH, Wang Y, Potroz MG, Ferhan AR, Weiss PS, Cho NJ


(* denotes equal first authors)

"Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H." 

ACS Nano 2016; 10(11), 10161-10172.


Zhdanov VP, Cho NJ

"Kinetics of Formation of a Protein Corona around Nanoparticles." 

Mathematical Biosciences 2016; 282, 82-90.

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