top of page

Complement-activation related Pseudoallergy

"Next-Generation Measurement Assay for Nanomedicine"

Complement-activation related  pseudoallergy (CARPA) is a potentially lethal acute immune toxicity caused by many intravenous drugs that contain nanoparticles or proteins. The integration of our group’s biomimetic membrane platform with state-of-the-art surface-based characterization tools has led to a promising new approach for real-time monitoring and better understanding of the complement activation process.



Fülöp TG, Nemes R, Mészáros T, Urbanics R, Kok RJ, Jackman JA, Cho NJ, Storm G, Szebeni J

"Complement Activation In Vitro and Reactogenicity of Superparamagnetic Iron-Oxide MRI Contrast Agents in Pigs: Correlation with Physicochemical Features and Clinical Information." 

Journal of Controlled Release 2017; 270, 268-274.


Yorulmaz Avsar S, Jackman JA, Kim MC, Yoon BK, Hunziker W, Cho NJ

"Immobilization Strategies for Functional Complement Convertase Assembly at Lipid Membrane Interfaces." 

Langmuir 2017; 33(29), 7332-7342.


Yorulmaz S, Jackman JA, Hunziker W, Cho NJ

"Influence of Membrane Surface Charge on Adsorption of Complement Proteins onto Supported Lipid Bilayers." 

Colloids and Surfaces B: Biointerfaces 2016; 148, 270-277.


Jackman JA, Mészáros T, Fülöp T, Urbanics R, Szebeni J*, Cho NJ*

"Comparison of Complement Activation-Related Pseudoallergy in Miniature and Domestic Pigs: Foundation of a Validatable Immune Toxicity Model." 

Nanomedicine: Nanotechnology, Biology, and Medicine 2016; 12(4), 933-943.


Yorulmaz S, Tabaei SR, Kim MH, Seo JE, Hunziker W, Szebeni J, Cho NJ

"Membrane Attack Complex Formation on a Supported Lipid Bilayer: Initial Steps towards a CARPA Predictor Nanodevice." 

European Journal of Nanomedicine 2015; 7(3), 245-255.

bottom of page