Publications | Engineering in Translational Science

KEY PUBLICATIONS

ENGINEERING IN TRANSLATIONAL SCIENCE

CARPA: “Next-Generation Measurement Assay for Nanomedicine”

Complement-activation related pseudoallergy (CARPA) is a potentially lethal acute immune toxicity caused by many intravenous drugs that contain nanoparticles or proteins. The integration of our group’s biomimetic membrane platform with state-of-the-art surface-based characterization tools has led to a promising new approach for real-time monitoring and better understanding of the complement activation process.

Back

Fülöp TG, Nemes R, Mészáros T, Urbanics R, Kok RJ, Jackman JA, Cho NJ, Storm G, Szebeni J

"Complement Activation In Vitro and Reactogenicity of Superparamagnetic Iron-Oxide MRI Contrast Agents in Pigs: Correlation with Physicochemical Features and Clinical Information."

Journal of Controlled Release 2017; 270, 268-274.

READ

Yorulmaz Avsar S, Jackman JA, Kim MC, Yoon BK, Hunziker W, Cho NJ

"Immobilization Strategies for Functional Complement Convertase Assembly at Lipid Membrane Interfaces."

Langmuir 2017; 33(29), 7332-7342.

READ

Yorulmaz S, Jackman JA, Hunziker W, Cho NJ

"Influence of Membrane Surface Charge on Adsorption of Complement Proteins onto Supported Lipid Bilayers."

Colloids and Surfaces B: Biointerfaces 2016; 148, 270-277.